Articles scientifiquesLogo Cohorte EGEA

1995-2025 liste complète des références (PDF)

Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults

Guillien A, K Niespodziana, M Mauclin, A Boudier, R Varraso, B Leynaert, O Dumas, N Le Moual, T Schlederer, N Bajic, K Borochova, P Errhalt, R Vernet, R Nadif, J Bousquet, E Bouzigon, R Valenta, V Siroux

Front Immunol 2024

Résumé l'article (PDF)

Trajectories of IgE sensitization to allergen molecules from childhood to adulthood and respiratory health in the EGEA cohort

Siroux V, Boudier A, Bousquet J, Dumas O, Just J, Le Moual N, Nadif R, Varraso R, Valenta R, Pin I

Allergy 2021;

Résumé l'article (PDF)

Long-term Air Pollution Exposure Is Associated With Increased Severity of Rhinitis in 2 European Cohorts

Burte E, Leynaert B, Marcon A, Bousquet J, Benmerad M, Bono R, Carsin AE, De Hoogh K, Forsberg B, Gormand F, Heinrich J, Just J, Nieuwenhuijsen M, Pin I, Stempfelet M, Sunyer J, Villani S, Künzli N, Siroux V, Jarvis D, Nadif R, Jacquemin B

J Allergy Clin Immunol, 145 (3), 834-842.e6, Mar 2020

Résumé l'article (PDF)

Genome-wide Interaction Study of Early-Life Smoking Exposure on Time-To-Asthma Onset in Childhood

Sugier PE, Sarnowski C, Granell R, Laprise C, Ege M, Margaritte_Jeannin P, Dizier MH, Minelli C, Moffart M, Lathrop M, Cookson WOC, Henderson AJ, Von Mutius E, Kogevinas M, Demenais F, Bouzigon E

Clin Exp Allergy, 49 (10), 1342-1351 Oct 2019

Résumé l'article (PDF)

Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Havet A, Li Z, Zerimech F, Sanchez M, Siroux V, Le Moual N, Brunekreef B, Kunzli N, Jacquemin B, Varraso R, Matran R, Nadif R

Environ Health18 (1), 90 2019 Oct 29.

Résumé l'article (PDF)

The role of socioeconomic status in the association of lung function and air pollution– a pooled analysis of three adult ESCAPE cohorts

Keidel D*, Anto JM, Basagaña X, Bono R, Burte E, Carsin AE, Forsberg B, Fuertes E, Galobardes B, Heinrich J, de Hoogh K, Jarvis D, Künzli N, Leynaert B, Marcon A, Le Moual N, de Nazelle A, Schindler C, Siroux S, Stempfelet M, Sunyer J, Temam S, Tsai MY, Varraso R, Jacquemin B, Probst-Hensch N

Int J Environ Res Public Health. 2019 May 29;16(11). pii: E1901. doi: 10.3390/ijerph16111901

Résumé l'article (PDF)

Data-driven adult asthma phenotypes are associated with asthma outcomes twenty years later

Boudier A, Chanoine S, Accordini S, Anto JM, Basagana X, Bousquet J, Demoly P, Garcia-Aymerich J, Gormand F, Heinrich J, Janson C, Kunzli N, Matran R, Pison C, Raherisson C, Sunyer J, Varraso R, Jarvis D, Leynaert B, pin I, Siroux V

Allergy. 2019 May;74(5):953-963. doi: 10.1111/all.13697.

Résumé l'article (PDF)

EGEA collection: a biobank devoted to asthma and asthma-related phenotypes

Nadif R, Bouzigon E, Le Moual N, Siroux V

Open Journal of Bioresources, 2019;4(1), p.5. DOI: http://doi.org/10.5334/ojb.24

Facteurs environnementaux favorisant le développement de l'asthme

Leynaert B, Le Moual N, Neukirch C, Siroux V, Varraso R

Presse Med. 2019 Mar;48(3 Pt 1):262-273. doi: 10.1016/j.lpm.2019.02.022

Résumé l'article (PDF)

Résumés en français de tous les articles de l’année 2018 (PDF)

sIgE and sIgG to airborne atopic allergens: coupled rather than inversely-related responses.

Aalberse R, Lupinek C, Siroux V, Nadif R, Just J, Bousquet J, Valenta R, Platts-Mills TA

Allergy. 2018 Nov;73(11):2239-2242. doi: 10.1111/all.13548.

Update of an occupational Asthma-Specific Job-Exposure Matrix to assess exposure to 30 specific agents

Le Moual N, Zock JP, Dumas O, Lytras T, Andersson E, Lillienberg L, Schlünssen V, Benke G, Kromhout H.

Occup Environ Med. 2018 Jul;75(7):507-514. doi: 10.1136/oemed-2017-104866.

Novel genes and insights in complete asthma remission

Vonk J, Nieuwenhuis MAE, Dijk FN, Boudier A, Siroux V, Bouzigon E, Probst-Hensch N, Imboden M, Keidel D, Sin D, Bosse Y, Hao K, Van den Berge M, Faiz A, Koppelman GH, Postma DS

Clin Exp Allergy. 2018 Oct;48(10):1286-1296. doi: 10.1111/cea.13181.

Association between air pollution and rhinitis incidence in two European cohorts

Burte E, Leynaert B, Bono R, Brunekreek B, Bousquet J, Carsin AE, De Hoogh K, Forsberg B, Gormang F, Heinrich J, Just J, Marcon A, Kunzli N, Nieuwenhuijsen M, Pin I, Stempfelet M, Sunyer J, Villani S, Siroux V, Jarvis D, Nadif R, Jacquemin B

Environ Int. 2018 Jun;115:257-266. doi: 10.1016/j.envint.2018.03.021.

The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

Siroux V, Ballardini N, Soler M, Lupinek M, Boudier A, Pin I, Just J, Nadir R, Anto JM, Melen E, Valenta R, Wickman M, Bousquet J

Allergy. 2018 Jul;73(7):1447-1458. doi: 10.1111/all.13410.

The COL5A3 and MMP9 genes interact in eczema susceptibility

Margaritte-Jeanin P, Babron MC, Laprise C, Lavielle N, Sarnowski C, Brossard M, Moffat M, Gagné-ouellet V, Etcheto A, Lathrop M, Just J, Cookson WO, Bouzigon E, Demenais F, Dizier MH

Clin Exp Allergy. 2018 Mar;48(3):297-305. doi: 10.1111/cea.13064.

A novel role for cilia function in atopy: ADGRV1 and DNAH5 interactions

Sugier PE,Brossard M*, Sarnowski C*, Vaysse A, Morin A, Pain L, Margaritte-Jeannin P, Dizier MH, Lathrop M, Laprise C, Demenais F, Bouzigon E

J Allergy Clin Immunol. 2018 May;141(5):1659-1667.e11. doi: 10.1016/j.jaci.2017.06.050.

Résumés en français de tous les articles de l’année 2017 (PDF)

Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma

Liu Y, Brossard M, Sarnowski C, Vaysse A, Moffatt M, Margaritte-Jeannin P, Llinares F, Dizier M-H, Lathrop M, Cookson W, Bouzigon E, Demenais F

Sci Rep. 2017 Apr 20;7(1):938. doi: 10.1038/s41598-017-01058-y

Prospective study of healthy eating and change in asthma symptoms according to smoking

Li Z, Rava M, Bédard A, Dumas O, Garcia-Aymerich J, Leynaert B, Pison C, Le Moual N, Romieu I, Siroux V, Camargo CA Jr, Nadif R, Varraso R

Br J Nutr. 2017 Feb;117(4):562-571. doi: 10.1017/S0007114517000368.

Functional variation in allelic methylomes underscore strong genetic contribution and reveal novel epigenetic alterations in the human epigenome

Cheung* WA, Shao* X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T*, Grundberg E*

Genome Biol. 2017 Mar 10;18(1):50. doi: 10.1186/s13059-017-1173-7

Blood cytokine profiles and subsequent risk of asthma symptom control in adults from the EGEA study

Akiki Z, Rava M, Gil Oscar D, Pin I, Le Moual N, Siroux V, Guerra S, Chamat S, Matran R, Colomer Montserrat F, Salameh P, Nadif R

Respir Med. 2017 Apr;125:57-64. doi: 10.1016/j.rmed.2017.03.002.

Adult onset asthma and interaction between genes and active tobacco smoking

Vonk JM, Scholtens S, Postma DS, Moffatt MF, Jarvis D, Ramasamy A, Wjst M, Omenaas, Bouzigon E, Demenais F, Nadif R, Siroux V, Polonikov A, Solodilova M, Ivanov V, Curjuric I, Imboden M, Kumar A, Probst-Hensch N, Ogorodova LM, Puzyrev VP, Bragina EY, Freidin MB, Nolte IM, Lifelines Cohort Study, Farrall AM, Cookson WOCM, Strachan DP, Koppelman GH, Boezen HM

PLoS One. 2017 Mar 2;12(3):e0172716. doi: 10.1371/journal.pone.0172716. eCollection 2017

Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies

Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier MH, Dumas O, Gonzales JR, Imboden M, Mehta AJ, Tubert-Bitter P, Zock JP, Jarvis D, Probst-Hensch NM, Demenais F, Nadif R

Environ Health Perspect. 2017 Feb;125(2):207-214. doi: 10.1289/EHP376.

Socioeconomic position and air pollution exposure in Western Europe: a multi-city analysis

Temam S, Burte E, Adam M, Antó JM, Basagaña X, Bousquet J, Carsin AE, Galobardes B, Keidel D, Kuenzli N, Le Moual N, Sanchez M, Sunyer J, Bono R, Brunekreef B, Heinrich J, Hoog K, Jarvis D, Marcon A, Modig L, Nadif R, Nieuwenhuijsen M, Pin I, Siroux V, Stempfelet M, Tsai MY, Probst-Hensch N, Jacquemin B

Environ Int. 2017 Apr;101:117-124. doi: 10.1016/j.envint.2016.12.026.

PTTG1IP and MAML3, novel GWAS genes for severity of hyperresponsiveness in adult asthma

Nieuwenhuis MAE, Vonk JM, Himes BE, Sernowski C, Minelli C, Jarvis D, Bouzigon E, Nickle DC, Laviolette M, Sin D, Weiss ST, van den Berge M, Koppelman GH, Postma DS

Allergy. 2017 May;72(5):792-801. doi: 10.1111/all.13062.

Mieux comprendre l'hétérogénéité et l'étiologie de l'asthme : synthèse des résultats récents de l'étude des facteurs génétiques et environnementaux de l'asthme (EGEA).

Nadif R, Dizier MH, Bouzigon E, Demenais F, Pin I, Siroux V, au nom du groupe coopératif d’EGEA.

La lettre du pneumologue, 2017; juin

Résumés en français de tous les articles de l’année 2016 (PDF)

Identification of a new locus at 16q12 associated with time-to-asthma onset

Sarnowski C, Sugier P-E, Granell R, Jarvis D, Dizier M-H, Ege M, Imboden M, Laprise C, Khusnutdinova E.K, Freidin M.B, Cookson W.O.C, Moffatt M, Lathrop M, Siroux V, Ogorodova L.M, Karunas A.S, James A, Probst-Hensch N.M, von Mutius E, Pin I, Kogevinas M, Henderson A.J, Demenais F, Bouzigon E

J Allergy Clin Immunol. 2016 Oct;138(4):1071-1080. doi: 10.1016/j.jaci.2016.03.018.

DNA methylation within MTNR1A mediates paternally transmitted genetic variant effect on asthma-plus-rhinitis.

Sarnowski C, Laprise C, Malerba G, Moffatt MF, Dizier MH, Morin A, Vincent QB, Rohde K, Esparza-Gordillo J, Margaritte-Jeannin P, Liang L, Lee YA, Bousquet J, Siroux V, Pignatti PF, Cookson WO, Lathrop M, Pastinen T, Demenais F, Bouzigon E.

J Allergy Clin Immunol. 2016 Sep;138(3):748-53. doi: 10.1016/j.jaci.2015.12.1341.

Interactive effect between DNAH9 gene and early-life tobacco smoke exposure on bronchial hyper-responsiveness in asthma-ascertained families

Dizier MH, Nadif R, Jeanin M, Barton SJ, Sarnowski C, Gagné-Ouellet V, Brossard M, Lavielle N, Just J, Lathrop M, Holloway JW, Laprise C, Bouzigon E, Demenais F

Eur Respir J. 2016 Apr;47(4):1072-81. doi: 10.1183/13993003.00849-2015.

Résumés en français de tous les articles de l’année 2015 (PDF)

Meta-analysis identifies 7 susceptibility loci involved in the atopic march

Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spucher BP, Baurecht H, Margaritte-Jeanin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun‐Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster‐Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell C, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA

Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804.

Facteurs génétiques et environnementaux de l’asthme et de l’allergie; Etude EGEA : Synthèse des résultats.

Bouzigon E, Nadif R, Le Moual N, Dizier MH, Aschard H, Boudier A, Bousquet J, Chanoine S, Donnay C, Dumas O, Gormand F, Jacquemin B, Just J, Margaritte-Jeannin P, Matran R, Pison C, Rage E, Rava M, Sarnowski C, Smit L.A.M, Temam S, Varraso R, Vignoud L, Lathrop M, Pin I, Demenais F, Kauffmann F, Siroux V.

Rev Mal Respir. 2015 Oct;32(8):822-40. doi: 10.1016/j.rmr.2014.12.005.

Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE).

Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F.

Environ Health Perspect. 2015 Jun;123(6):613-21. doi: 10.1289/ehp.1408206.

A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.

Bouziguon E, Nadif R, Thompson EE, Concas MP, Kuldanek S, Du G, Brossard M, Lavielle N, Sarnowski C, Vaysse A, Dessen P, van der Valk RJP, Duijts L, Henderson AJ, Jaddoe VWV, de Jongste JC, GABRIEL consortium, EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Casula S, Biino G, Dizier MH, Pin I, Matran R, Lathrop M, Pirastu M, Florence Demenais F, Ober C.

Clin Experim Allergy 2015 Apr;45(4):797-806

Perceived long-term change in respiratory health: validity and predictive ability.

Sanchez M, Varraso R, Bousquet J, Clavel-Chapelon F, Pison C, Kauffmann F, Humbert M, Siroux V.

Respir Med 2015 Feb;109(2):188-99

Long-term exposure to air pollution and lung function in adults: multicentre cohort study and meta-analysis, the ESCAPE project.

Adam M, Schikowski T, Carsin A.E, Cai Y, Jacquemin B, Sanchez M, Vierkötter A, Marcon A, Keidel D, Sugiri D, Kanani Z.A, Nadif R, Siroux V, Hardy R, Kuh D, Rochat T, Bridevaux P.O, Eeftens M, Tsai M.Y, Villani S, Chandra Phuleria H, Birk M, Cyrys J, Cirach M, de Nazelle A, Nieuwenhuijsen M, Forsberg B, de Hoogh K, Declerq C, Bono R, Piccioni P, Quass U, Heinrich J, Jarvis D, Pin I, Beelen R, Hoek G, Brunekreef B, Schindler C, Sunyer J, Krämer U, Kauffmann F, Hansell A.L, Künzli N, Probst-Hensch N.

Eur Respir J 2015 Jan;45(1):38-50.

Long-term benefits of inhaled corticosteroids in asthma: the propensity score method

Chanoine S, Dumas O, Benmerad M, Pison C, Varraso R, Gormand F, Just J, Le Moual N, Bedouch P, Bousquet J, Kauffmann F, Pin I, Siroux V

Pharmacoepidemiol Drug Saf. 2015 Mar;24(3):246-55

Résumés en français de tous les articles de l’année 2014 (PDF)

HLA-II variants and adult-onset asthma: does occupational allergen exposure play a role?

Smit LAM, Strachan D.P, Vermeulen R, de Bakker P.I.W, Demenais F, Dumas O, Carsin A-E, Cullinan P, Curjuric I, Ghosh RE, Heederik D, Imboden M, Jarvis D, Lathrop M, Le Moual N, Mehta A, Miedinger D, Sigsgaard T, Siroux V, Vernez D, Zock JP, Kauffmann F, Probst-Hensch N, Kogevinas M, Bouzigon E

Eur Respir J. 2014 Nov;44(5):1234-42

Use of household cleaning products, exhaled nitric oxide and lung function in women

Le Moual N, Rava M, Siroux V, Matran R, Nadif R, on behalf of the Epidemiological Study on the Genetics and Environment of Asthma

Eur Respir J 2014 Sep;44(3):816-8

The nuclear factor I_A (NFIA) gene is associated with the asthma plus rhinitis phenoype

Dizier MH, Margaritte-Jeannin P, Madore AM, Moffatt M, Brossard M, Lavielle N , Sarnowski C, Just J, Cookson W, Lathrop M, Laprise C, Bouzigon E, Demenais F

J Allergy Clin Immunol.2014 Sep;134(3):576-582

Novel childhood asthma genes interact with in utero and early life tobacco smoke exposure.

Scholtens S, Postma DS, Moffatt MF, Panasevich S, Granell R, Henderson AJ, Melén E, Nyberg F, Pershagen G, Jarvis D, Ramasamy A, Wjst M, Svanes C, Bouzigon E, Demenais F, Kauffmann F, Siroux V, von Mutius E, Ege MJ, Braun-Fahrländer C, Genuneit J and the GABRIELA study group, Brunekreef B, Smit HA, Wijga AH, Kerkhof M, Curjuric I, Imboden M, Thun GA, Probst-Hensch N, Freidin MB, Iu. Bragina E, Deev IA, Puzyrev VP, Daley D, Park J, Becker A, Chan-Yeung M, Kozyrskyj AL, Pare P, Marenholz I, Lau S, Keil T, Lee Y, Kabesch M, Wijmenga C, Franke L, Nolte IM, Vonk J, Kumar A, Farrall M, Cookson WOCM, Strachan DP, Koppelman GH, Boezen HM.

J Allergy Clin Immunol. 2014 Mar;133(3):885-8.

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

Van der Valk RJP, Duijts L, Timpson NJ, Salam MT, Standl M, Curtin JA, Genuneit J, Kerhof M, Kreiner-Møller E, Cáceres A, Gref A, Liang LL, H Rob Taal, Bouzigon E, Demenais F, Nadif R, Ober C, Thompson EE, Estrada K, Hofman A, Uitterlinden AG, van Duijn C, Rivadeneira F, Li X, Eckel SP, Berhane K, Gauderman WJ, Granell R, Evans DM, St Pourcain B, McArdle W, Kemp JP, Davey Smith G, Carla MT Tiesler CMT, Flexeder C, Simpson A, Murray CS, Fuchs O, Postma DS, Bønnelykke K, Torrent M, Andersson M, Sleiman P, Hakonarson H, Cookson WO, Moffatt MF, Paternoster L, Melén E, Sunyer J, Bisgaard H, Koppelman GH, Ege M, Custovic A, Heinrich J, Gilliland FD, Henderson AJ, Jaddoe VWV, de Jongste JC for the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium.

J Allergy Clin Immunol. 2014 Jul;134(1):46-55

Résumés en français de tous les articles de l’année 2013 (PDF)

Impact of Geocoding Methods on Associations between Long-term Exposure to Urban Air Pollution and Lung Function

Jacquemin B, Lepeule J, Boudier A, Arnould C, Benmerad M, Chappaz C, Ferran J, Kauffmann F, Morelli X, Pin I, Pison C, Rios I, Temam S, Künzli N, Slama R, Siroux V

Environ Health Perspect. 2013 Sep;121(9):1054-60

10 Year-Follow up of Cluster-Based Asthma Phenotypes in Adults. A Pooled Analysis of Three Cohorts

Boudier A, Curjuric I, Basagaña X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, Janson C, Künzli N, Leynaert B, de Marco R, Rochat T, Schindler C, Varraso R, Pin I, Probst-Hensch N, Sunyer J, Kauffmann F, Siroux V.

Am J Respir Crit Care Med. 2013 Sep 1;188(5):550-60. doi: 10.1164/rccm.201301-0156OC.

Genome-wide association study of body mass index in 24,000 Caucasian individuals with and without asthma

Melén E, Granell R, Kogevinas M, Strachan D, Gonzalez JR, Wjst M, Jarvis D, Ege M, Braun-Fahrländer C, Genuneit J, Horak E, Bouzigon E, Demenais F, Kauffmann F, Siroux V, Michel S, von Berg A, Heinzmann A, Kabesch M, Probst-Hensch NM, Curjuric I, Imboden M, Rochat T, Henderson J, Sterne JAC, McArdle WL, Hui J, James AL, Musk AW, Palmer LJ, Becker A, Kozyrskyj AL, Chan-Yeung M, Park JE, Leung A, Daley D, Freidin MB, Deev IA, Ogorodova LM, Puzyrev VP, Celedón J, Soto-Quiros M, Avila L, Bergström A, Söderhäll C, Kull I, Scholtens S, Boezen HM, Koppelman GH, Wijga AH, Marenholz I, Esparza-Gordillo J, Lau S, Lee YA, Farrall M, Kumar A, Moffatt MF, Cookson WOCM, Weiss ST, Lasky-Su J

Clin Exp Allergy. 2013 Apr;43(4):463-74. doi: 10.1111/cea.12054.

Résumés en français de tous les articles de l’année 2012 (PDF)

Plasma and exhaled breath condensate nitrite-nitrate level in relation to environmental exposures in adults in the EGEA study

Rava M, Varraso R, Huyvaert H, Decoster B, Le Moual N, Jacquemin B, Künzli N, Kauffmann F, Zerimech F, Matran R, Nadif R

Nitric Oxide 2012;27:169-175

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma

Dizier MH, Margaritte-Jeannin P, Madore AM, Esparza-Gordillo J, Moffatt M, Corda E, Monier F, Guilloud-Bataille M, Franke A, Weidinger S, Annesi-Maesano I, Just J, Pin I, Kauffmann F, Cookson W, Lee YA, Laprise C, Lathrop M, Bouzigon E, Demenais F

J Allergy Clin Immunol 2012; 129:1547-1553.e3

Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status

Bouzigon E, Monier F, Boussaha M, Le Moual N, Huyvaert H, Matran R, Letort S, Bousquet J, Pin I, Lathrop M, Kauffmann F, Demenais F, Nadif R, on behalf of the EGEA Cooperative Group

PLoS One 2012;7(5):e36672. Epub 2012 May 9.

Domestic use of cleaning sprays and asthma activity in women

Le Moual N, Varraso R, Siroux V, Dumas O, Nadif R, Pin I, Zock JP, Kauffmann F, on behalf of the Epidemiological Study on the Genetics and Environment of Asthma.

Eur Respir J 2012 Dec;69(12):883-9

Transient receptor potential (TRP) genes, smoking, occupational exposures and cough in adults.

Smit LA, Kogevinas M, Antó JM, Bouzigon E, González JR, Le Moual N, Kromhout H, Carsin AE, Pin I, Jarvis D, Vermeulen R, Janson C, Heinrich J, Gut I, Lathrop M, Valverde MA, Demenais D, Kauffmann F.

Respir Res 2012 Mar 23;13(1):26

Genome wide association study of lung function decline in adults with and without asthma

Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, Wilk JB, Vonk J, Thun GA, Siroux V, Nadif R, Monier F, Gonzalez JR, Wjst M, Heinrich J, Loehr L, Franceschini N, North KE, Koppelman GH, Guerra S, Kronenberg F, Lathrop, Moffatt MF, O'Connor GT, Strachan DP, Postma D, London SJ, Schindler C, Kogevinas M, Kauffmann F, Jarvis DL, Demenais F, Probst-Hensch

J Allergy Clin Immunol 2012 ; 129 : 1218-28 Mar 15. [Epub ahead of print]

Asthma control assessed in the EGEA epidemiological survey and health-related quality of life

Siroux V, Boudier A, Bousquet J, Vignoud L, Gormand F, Just J, Le Moual N, Leynaert B, Nadif R, Pison C, Scheinmann P, Vervloet D, Antó JM, Kauffmann F, Pin I

Respir Med 2012; 106: 820-828. Feb 22. [Epub ahead of print]

Résumés en français de tous les articles de l’année 2011 (PDF)

Under-estimation of self-reported occupational exposure by questionnaire in hospital workers.

Donnay C, Denis MA, Magis R, Fevotte J, Massin N, Dumas O, Pin I, Choudat D, Kauffmann F, Le Moual N.

Occ Environ Med 2011; 68:611-7

Usefulness of a new dialysis device adapted to small volume of red blood cells and its interest in epidemiology.

Zerimech F, Huyvaert H, Matran R, Nadif R

Clin Biochem 2011 ; 44:739-741

Do young adults with childhood asthma avoid occupational exposures at first hire?

Dumas O, Smit LAM, Kromhout H, Siroux V, Nadif R, Vermeulen R, Heederik D, Hery M, Choudat D, Kauffmann F, Le Moual N, on behalf of the Epidemiological Study on the Genetics and Environment of Asthma

Eur Respir J 2011; 37: 1043 - 1049

Résumés en français de tous les articles de l’année 2010 (PDF)

A Large-Scale, consortium-based Genomewide Association study of asthma.

Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WOCM, for the GABRIEL Consortium*.

N Engl J Med 2010; 363 : 1211-21

Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults.

Nadif R, Matran R, Maccario J, Bechet M, Le Moual N, Scheinmann P, Bousquet J, Kauffmann F, Pin I, on behalf of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA).

Ann Allergy Asthma Immunol 2010;104:385-93

Meta analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier MH, Duffy DL, Evans DM, Ferreira MAR, Kere J, Laitinen T, Malerba G, Meyers DA, Moffatt M, Martin NG, Ng MY, Pignatti PF, Wjst M, Kauffmann F, Demenais F, Lewis CM.

Eur J Hum Gen 2010;18(6):700-6

17q21 variants modify the association between early respiratory infections and asthma

Smit LAM, Bouzigon E, Pin I, Siroux V, Monier F, Aschard H, Bousquet J, Gormand F, Just J, Le Moual N, Nadif R, Scheinmann P, Vervloet D, Lathrop M, Demenais F, Kauffmann F, EGEA Cooperative group

Eur Respir J 2010; 36:57-64 [2009 Dec 23 Epub ahead of print]

Résumés en français de tous les articles de l’année 2009 (PDF)

Phenotypic determinants of uncontrolled asthma

Siroux V, Boudier A, Bousquet J, Bresson JL, Cracowski JL, Ferran J, Gormand F, Just J, Le Moual N, Morange S, Nadif R, Oryszczyn MP, Pison C, Scheinmann P, Varraso R, Vervloet D, Pin I, Kauffmann F on behalf of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA).

J Allergy Clin Immunol 2009 ; 184 : 681-687 - Aug 8. [Epub ahead of print]

Sex-specific effect of IL9 polymorphisms on lung function and polysensitization

Aschard H, Bouzigon E, Corda E, Ulgen A, Dizier MH, Gormand F, Lathrop M, Kauffmann F, Demenais F, on behalf of the EGEA cooperative group.

Genes and Immunity 2009 ; 10 :559-565

CD14 and Toll-like receptor gene polymorphisms, country living, and asthma in adults

Smit LAM, Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, Demenais F, Kauffmann F on behalf of the EGEA cooperative group.

Am J Respir Crit Care Med 2009; 179: 363-368

Heterogeneity of asthma according to blood inflammatory patterns.

Nadif R, Siroux V, Oryszczyn MP, Ravault C, Pison C, Pin I, Kauffmann F on behalf of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA)

Thorax 2009;64:374-80

Are asymptomatic airway hyperresponsiveness and allergy risk factors for asthma? A longitudinal study [letter].

Rage E, Siroux V, Le Moual N, Pin I, Kauffmann F.

Eur Respir J 2009 Jan;33(1):218-9

Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults

Rage E, Jacquemin, Nadif R, Oryszczyn MP, Siroux V, Aguilera I, Kauffmann F, Künzli N on behalf of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA)

Allergy 2009 Jan;64(1):40-6. Epub 2008 Nov 28

Résumés en français de tous les articles de l’année 2008 (PDF)

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J, Chateigner N, Gormand F, Just J, Le Moual N, Scheinmann P, Siroux V, Vervloet D, Zelenika D, Pin I, Kauffmann F, Lathrop M, Demenais F.

N Engl J Med 2008 ; 359 :1985-94

Replication of association between ADAM33 polymorphisms and psoriasis

Siroux V, Bouzigon E, Dizier MH, Pin I, Demenais F, Kauffmann F on behalf of the EGEA cooperative group

Plos one 2008 ;3 :e2448

Genome-wide evidence for linkage of a new region (11p14) to Atopic Dermatitis and Allergic Diseases

Guilloud-Bataille M, Bouzigon E, Annesi-Maesano I, Bousquet J, Charpin D, Gormand F, Hochez J, Just J, Lemainque A, Le Moual N, Matran R, Neukirch F, Oryszczyn MP, Paty E, Pin I, Vervloet D, Kauffmann F, Lathrop M, Demenais F, Dizier MH

Human Genetics 2008;122 :605-14

Résumés en français de tous les articles de l’année 2007 (PDF)

Enquête de satisfaction auprès de sujets participant à une recherche épidémiologique.

Tournillon-Daurès S, Ravault C, Ferran J, Pin I, Kauffmann F et le groupe coopératif EGEA.

Santé Publique 2007; 19 : 461-470

Scores of asthma and asthma severity reveal new regions of linkage in EGEA families

Bouzigon E, Siroux V, Dizier MH, Lemainque A, Pison C, Lathrop M, Kauffmann F, Demenais F, Pin I

Europ Respir J 2007 ; 30 : 253-259

Evidence for a pleiotropic QTL on chormosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families

Bouzigon E, Ulgen A, Dizier MH, Siroux V, Lathrop M, Kauffmann F, Pin I, Demenais F

Hum Genet 2007 ; 121:711-719

Evidence for gene x smoking exposure interactions in a genome-wide linkage screen of asthma and bronchial hyper-responsiveness in EGEA families

Dizier MH, Bouzigon E, Guilloud-Bataille M, Siroux V, Lemainque A, Boland A, Lathrop M, Demenais F

Europ J Hum Gen 2007 ;63 :162-167

Facteurs environnementaux de l'asthme sévère et de l'allergie : résultats de l'étude EGEA

Siroux V, Oryszczyn MP, Varraso R, Le Moual N, Bousquet J, Charpin D, Gormand F, Kennedy S, Maccario J, Pison C, Rage E, Scheinmann P, Vervloet D, Pin I, Kauffmann F.

Rev Mal Respir 2007 ; 24 : 599-608

Evidence for a locus in 1p31 region specifically linked to the co-morbidity of asthma and allergic rhinitis in the EGEA study.

Dizier MH, Bouzigon E, Guilloud-Bataille M, Genin E, Oryszczyn MP, Annesi-Maesano I, Demenais F.

Hum Hered 2007;63:162-167

Résumés en français de tous les articles de l’année 2005 (PDF)

Genome screen in the French EGEA study : detection of linked regions shared or not shared by allergic rhinitis and asthma

Dizier MH, Bouzigon E, Guilloud-Bataille M, Bétard C, Bousquet J, Charpin D, Gormand F, Hochez J, Just J, Lemainque A, Le Moual N, Matran R, Neukirch F, Oryszczyn MP, Paty E, Pin I, Vervloet D, Kauffmann F, Lathrop M, Demenais F, Annesi-Maesano I.

Genes Immun 2005 ; 6:95-102.

Asthma severity is associated with body mass index and early menarche in women.

Varraso R, Siroux V, Maccario J, Pin I, Kauffmann F on behalf of the Epidemiological Study on the genetics and Environment of Asthma (EGEA).

Am J Respir Crit Care Med 2005 ; 171:334-339

Résumés en français de tous les articles de l’année 2004 (PDF)

Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families

Bouzigon E, Dizier MH, Krähenbühl C, Torchard D, Annesi-Maesano I, Betard C, Bousquet J, Charpin D, Gormand F, Guilloud-Bataille M, Just J, Le Moual N, Maccario J, R Matran, Neukirch F, Oryszczyn MP, Paty E, Pin I, Rosenberg-Bourgin M, Vervloet D, Kauffmann F, Lathrop M, Demenais F

Hum Mol Gen 2004 ; 13: 3103-3113

Caractère multidimensionnel de la sévérité de l'asthme dans l'enquête EGEA Multidimensional character of asthma severity in the EGEA study

Siroux V, Kauffmann F, Pison C, Pin I.

Rev Mal Respir 2004 ; 21:917-924

Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands

Bouzigon E, Chaudru V, Carpentier AS, Dizier MH, Oryszczyn MP, Maccario J, Kauffmann F, Demenais F

Eur J Hum Gen 2004 ; 12:955-63

Influence of asthma on the validity of reported lifelong environmental tobacco smoke in the EGEA study

Siroux V, Guilbert P, Le Moual N, Oryszczyn MP, Kauffmann F.

Eur J Epidemiol 2004 ; 19 : 841-49

Résumés en français de tous les articles de l’année 2003 (PDF)

Allergy markers in adults in relation to the timing of pet exposure in the EGEA study

Oryszczyn MP, Annesi-Maesano I, Charpin D, Kauffmann F

Allergy 2003 ; 58:1136-1143

Indication of linkage and genetic heterogeneity for asthma and atopy on chromosomes 8p and 12q in 107 French EGEA families

Dizier MH, Quesneville H, Besse-Schmittler C, Guilloud-Bataille M, Selinger-Lenenman H, Clerget-Darpoux F, Demenais F.

Europ J Hum Gen 2003 ; 11:590-596

Relationships of allergic sensitisation, total IgE and blood eosinophils to asthma severity in children of the EGEA Study

Siroux V, Oryszczyn MP, Paty E, Kauffmann F, Pison C, Vervloet D, Pin I

Clin Experim Allergy 2003 ; 33:746-751

Triggering factors in intrinsic asthma in the Epidemiological study on the Genetics and Environment of asthma, bronchial hyperresponsiveness and atopy (EGEA study)

Charpin D, Ramadour M, Lanteaume A, Vervloet D

J Asthma 2003;40:87-91

Résumés en français de tous les articles de l’année 2002 (PDF)

Allergic versus non allergic asthma : what makes the difference ?

Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D and the EGEA cooperative group

Allergy 2002 ; 57:607-613

Construction and validation of a questionnaire in respiratory epidemiology. Example of the questionnaire of the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA)

Kauffmann F, Annesi-Maesano I, Liard R, Paty E, Faraldo B, Neukirch F, Dizier MH

Rev Mal Respir 2002; 19 : 323-333

The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsivenes and atopy.

Kauffmann F, Oryszczyn MP, Maccario J

Clin Experim Allergy 2002 ;32:379-86

Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA) -Synthesis of the first results

Kauffmann F, Dizier MH, Oryszczyn MP, Le Moual N, Siroux V, Kennedy S, Annesi-Maesano I, Bousquet J, Charpin D, Feingold J, Gormand F, Grimfeld A, Hochez J, Lathrop M, Matran R, Neukirch F, Paty E, Pin I, Demenais F

Rev Mal Respir 2002 ; 19:63-72

Résumés en français de tous les articles de l’année 2001 (PDF)

Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families

Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, Kauffmann F, Clerget-Darpoux F, Demenais F

Eur J Hum Gen 2001 ; 9 : 867-872

Epidemiological study of the Genetics and Environment of Asthma, Bronchial hhyperresponsiveness and atopy (EGEA)- Protocol and potential selection factors

Kauffmann F, Dizier MH, Annesi-Maesano I, Bousquet J, Charpin D, Demenais F, Ecochard D, Feingold J, Gormand F, Grimfeld A, Lathrop M, Matran R, Neukirch F, Paty E, Pin I, Pison C, Scheinmann P, Vervloet D, Lockhart A.

Rev Epidémiol Santé Publique 2001 ; 49 : 343-356

CFTR and asthma in the French EGEA study.

De Cid R, Chomel JC, Lazaro C, Sunyer J, Baudis M, Casals T, Le Moual N, Kitzis A, Feingold J, Anto J, Estivill X, Kauffmann F.

Eur J Hum Gen 2001 ;9:67-69

Résumés en français de tous les articles de l’année 2000 (PDF)

Genome screen for asthma and related phenotypes in the French EGEA study

Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, Annesi-Maesano I, Boussaha M, Bousquet J, Charpin D, Degioanni A, Gormand F, Grimfeld A, Hochez J, Hyne G, Lockhart A, Luillier-Lacombe G, Matran R, Meunier F, Neukirch F, Pacheco Y, Parent V, Paty E, Pin I, Pison C, Scheinmann P, Thobie N, Vervloet D, Kauffmann F, Feingold J, Lathrop M and Demenais F.

Am J Respir Crit Care Med 2000 ;162 :1812-1818

Smoking and asthma.

Siroux V, Pin, Oryszczyn MP, Le Moual N, Kauffmann F.

Eur Respir J 2000 ; 16 :575(correspondence)

Development of an asthma specific job exposure matrix and its application in the EGEA study.

Kennedy SM, Le Moual N, Choudat D, Kauffmann F.

Occup Environ Med 2000;57:635-641

Relationships of active and passive smoking to total IgE in adults of EGEA - (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy).

Oryszczyn MP, Annesi-Maesano I, Charpin D, Paty E, Maccario J, Kauffmann F.

Am J Respir Crit Care Med 2000 ;161 :1241-1246

Relationships of active smoking to asthma and asthma severity in the EGEA study.

Siroux V, Pin I, Oryszczyn MP, Le Moual N, Kauffmann F.

Eur Respir J 2000 ;15 :470-477

Segregation analysis of IgE levels in 335 French families (EGEA) using different strategies to correct for the ascertainment through a correlated trait (asthma).

Sampogna F, Demenais F, Hochez J, Oryszczyn MP, Maccario J, Kauffmann F, Feingold J, Dizier MH.

Genet Epidemiol 2000 ; 18 :128-142

Résumés en français de tous les articles de l’année 1999 (PDF)

EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy) - Descriptive characteristics

Kauffmann F, Dizier MH, Annesi-Maesano I, Bousquet J, Charpin D, Demenais F, Ecochard D, Feingold J, Gormand F, Grimfeld A, Lathrop M, Matran R, Neukirch F, Paty E, Pin I, Pison C, Scheinmann P, Vervloet D, Lockhart A.

Clin Exp Allergy 1999 ; 29 (suppl 4):17-21

Résumés en français de tous les articles de l’année 1998 (PDF)

DF508 heterozygosity and asthma

Kauffmann F, Chomel JC, Kitzis A, Feingold J, on behalf of the EGEA cooperative group.

Lancet 1998 ; 352:985-986

Résumés en français de tous les articles de l’année 1997 (PDF)

Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy (EGEA) - Phenotype issues

Kauffmann F, Dizier MH, Pin I, Paty E, Gormand F, Vervloet D, Bousquet J, Neukirch F, Annesi I, Oryszczyn MP, Lathrop M, Demenais F, Lockhart A, Feingold J.

Am J Respir Crit Care Med 1997; 156 : S123-S129

EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy). Design issues.

Kauffmann F, Dizier MH on behalf of the EGEA cooperative group.

Clin Exp Allergy 1995; 25 (suppl 2) : 19-22