The EGEA cohort

Epidemiological study of genetic factors
and environmental factors of asthma,
hyperreactivity bronchial and atopy.

The latest results

Viral infections in childhood, especially to rhinovirus (RV) and respiratory syncytial virus (RSV), are associated with asthma inception and exacerbation. However, little is known about the role of RV- and RSV-specific antibodies in childhood versus adult asthma. Our results suggest that the association between respiratory virus-specific antibody levels and asthma…

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Mauclin M et al. - Association between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults - J Allergy Clin Immunol Glob. 2024 Sep 17

Exposure to respiratory viruses is a major cause of morbidity and affects virus-specific antibody (IgG) levels. Little is known about the determinants associated with the immune response to these viruses. We investigated the determinants of specific IgG responses to respiratory syncytial virus (RSV) and rhinovirus (RV) in children and adults.…

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Guillien A et al. - Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults - Front Immunol 2024

Thanks to the follow-up of the EGEA population, which enabled repeated assessment of cleaning product exposure and respiratory health, a recent study suggests that long-term weekly use of spray cleaning products may have a negative effect on the evolution of asthma symptoms.

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Pacheco Da Silva E* et al. - Longitudinal associations of household use of cleaning agents and asthma symptoms in women: the EGEA study - Occup Environ Med. 2023 Apr

News

EGEA4 follow-up 01/12/2024

01/12/2024

The new follow-up of the EGEA4 cohort is ongoing. All participants have been contacted by mail. A big thank you…

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EGEA annual seminar 2025

01/12/2024

The next annual seminar of the EGEA cohort will take place on March 27 and 28, 2025 in Grenoble. Each…

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2120

participants in total since the beginning of EGEA (2047 EGEA1 / 1601 EGEA2 / 1557 EGEA3)

phases of the study

years of follow-up

66000

tubes of biological samples stored

> 150

scientific publications

> 200

scientific communications at international conferences

The EGEA cohort

in a few words

The epidemiological EGEA cohort (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy) was initiated in 1991 to meet the following general objectives:

to identify the genetic factors of asthma
to identify the environmental factors of asthma
to clarify the clinical heterogeneity of asthma.

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Who participates in the study?

In the first phase of the EGEA study (EGEA1), 388 asthma families and 415 participants from the general population were included, representing 2047 participants with or without asthma.
During the second phase of the study, 73 new family members joined the study. A total of 2120 participants participated in at least one phase of the study…

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